Recent News at Kaelin Lab
Publications:
2025
Jiang Q, Braun DA, Clauser KR, Ramesh V, Shirole NH, Duke-Cohan JE, Nabilsi N, Kramer NJ, Forman C, Lippincott IE, Klaeger S, Phulphagar KM, Chea V, Kim N, Vanasse AP, Saad E, Parsons T, Carr-Reynolds M, Carulli I, Pinjusic K, Jiang Y, Li R, Syamala S, Rachimi S, Verzani EK, Stevens JD, Lane WJ, Camp SY, Meli K, Pappalardi MB, Herbert ZT, Qiu X, Cejas P, Long HW, Shukla SA, Van Allen EM, Choueiri TK, Churchman LS, Abelin JG, Gurer C, MacBeath G, Childs RW, Carr SA, Keskin DB, Wu CJ, Kaelin WG Jr. HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy. Cell. 2025 Feb 25:S0092-8674(25)00156-4. doi: 10.1016/j.cell.2025.01.046. Online ahead of print. PMID: 40023154
2024
Stransky LA, Gao W, Schmidt LS, Bi K, Ricketts CJ, Ramesh V, James A, Difilippantonio S, Ileva L, Kalen JD, Karim B, Jeon A, Morgan T, Warner AC, Turan S, Unite J, Tran B, Choudhari S, Zhao Y, Linn DE, Yun C, Dhandapani S, Parab V, Pinheiro EM, Morris N, He L, Vigeant SM, Pignon JC, Sticco-Ivins M, Signoretti S, Van Allen EM, Linehan WM, Kaelin WG Jr. Toward a CRISPR-based mouse model of Vhl-deficient clear cell kidney cancer: Initial experience and lessons learned. Proc Natl Acad Sci U S A. 2024 Oct 8;121(41):e2408549121. doi: 10.1073/pnas.2408549121. Epub 2024 Oct 4. PMID: 39365820
Abu-Remaileh M, Persky NS, Lee Y, Root DE, Kaelin WG Jr. Total loss of VHL gene function impairs neuroendocrine cancer cell fitness due to excessive HIF2α activity. Proc Natl Acad Sci U S A. 2024 Oct;121(40):e2410356121. doi: 10.1073/pnas.2410356121. Epub 2024 Sep 25. PMID: 39320914 Free PMC article.
Wyant GA, Jiang Q, Singh M, Qayyum S, Levrero C, Maron BA, Kaelin WG Jr. Induction of DEPP1 by HIF Mediates Multiple Hallmarks of Ischemic Cardiomyopathy. Circulation. 2024 Jun 17. doi: 10.1161/CIRCULATIONAHA.123.066628. Online ahead of print. PMID: 38881449
Lampson BL, Ramίrez AS, Baro M, He L, Hegde M, Koduri V, Pfaff JL, Hanna RE, Kowal J, Shirole NH, He Y, Doench JG, Contessa JN, Locher KP, Kaelin WG Jr. Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB. Cell. 2024 Apr 25;187(9):2209-2223.e16. doi: 10.1016/j.cell.2024.03.022. PMID: 38670073
Tamar Berger, MD, PhD was selected as a Lubin Family Foundaton Scholar.
2023
Publications:
Shi DD, Lee JH, Wang AC, Khanal J, Gao W, Kaelin WG Jr, McBrayer SK. Protocol to establish a genetically engineered mouse model of IDH1-mutant astrocytoma. STAR Protoc. 2023 May 6;4(2):102281. doi: 10.1016/j.xpro.2023.102281. Online ahead of print. PMID: 37149859 Free PMC article.
Shirole NH, Kaelin WG Jr. von-Hippel Lindau and Hypoxia-Inducible Factor at the Center of Renal Cell Carcinoma Biology. Hematol Oncol Clin North Am. 2023 Oct;37(5):809-825. doi: 10.1016/j.hoc.2023.04.011. Epub 2023 Jun 1. PMID: 37270382 Review.
Shi DD, Kaelin WG. The INDIGO trial: Precision medicine finally comes to glioma. Neuro Oncol. 2023 Nov 2;25(11):1918-1919. doi: 10.1093/neuonc/noad162. PMID: 37698505 No abstract available.
Adam Kibel, MD has been appointed the inaugural incumbent of the DiNovi Distinguished Chair in Urology at Brigham and Women's Hospital.
Nitin Shirole, PhD received a Career Enhancement Program Award- (Funded by Dana Farber/Harvard Cancer Center Kidney Cancer Spore)
2022
Diana Shi, MD was among the inaugural recipients of a Lubin Family Foundation Scholar Award.
Qinqin Jiang, PhD received a Kidney Cancer Research Program Postdoctoral Fellowship Award from DoD.
Nitin Shirole, PhD received a Hope Funds Sakonnet Fellowship- (Funded by Hope Funds for Cancer Research)
2021
Alumni News: October 2021 Javid Moslehi, MD will become Chief of Cardio-Oncology at UCSF Cardiology! Congrats Javid!!
Publication: Targeting oncoproteins with a positive selection assay for protein degraders
advances.sciencemag.org/content/advances/7/6/eabd6263.full.pdf
2020
The political battle over masks is making us lose the war on COVID-19
Opinion: Why we can’t cure cancer with a moonshot
2019
William Kaelin's 2019 Nobel Prize in Physiology or Medicine
2025
Jiang Q, Braun DA, Clauser KR, Ramesh V, Shirole NH, Duke-Cohan JE, Nabilsi N, Kramer NJ, Forman C, Lippincott IE, Klaeger S, Phulphagar KM, Chea V, Kim N, Vanasse AP, Saad E, Parsons T, Carr-Reynolds M, Carulli I, Pinjusic K, Jiang Y, Li R, Syamala S, Rachimi S, Verzani EK, Stevens JD, Lane WJ, Camp SY, Meli K, Pappalardi MB, Herbert ZT, Qiu X, Cejas P, Long HW, Shukla SA, Van Allen EM, Choueiri TK, Churchman LS, Abelin JG, Gurer C, MacBeath G, Childs RW, Carr SA, Keskin DB, Wu CJ, Kaelin WG Jr. HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy. Cell. 2025 Feb 25:S0092-8674(25)00156-4. doi: 10.1016/j.cell.2025.01.046. Online ahead of print. PMID: 40023154
2024
Stransky LA, Gao W, Schmidt LS, Bi K, Ricketts CJ, Ramesh V, James A, Difilippantonio S, Ileva L, Kalen JD, Karim B, Jeon A, Morgan T, Warner AC, Turan S, Unite J, Tran B, Choudhari S, Zhao Y, Linn DE, Yun C, Dhandapani S, Parab V, Pinheiro EM, Morris N, He L, Vigeant SM, Pignon JC, Sticco-Ivins M, Signoretti S, Van Allen EM, Linehan WM, Kaelin WG Jr. Toward a CRISPR-based mouse model of Vhl-deficient clear cell kidney cancer: Initial experience and lessons learned. Proc Natl Acad Sci U S A. 2024 Oct 8;121(41):e2408549121. doi: 10.1073/pnas.2408549121. Epub 2024 Oct 4. PMID: 39365820
Abu-Remaileh M, Persky NS, Lee Y, Root DE, Kaelin WG Jr. Total loss of VHL gene function impairs neuroendocrine cancer cell fitness due to excessive HIF2α activity. Proc Natl Acad Sci U S A. 2024 Oct;121(40):e2410356121. doi: 10.1073/pnas.2410356121. Epub 2024 Sep 25. PMID: 39320914 Free PMC article.
Wyant GA, Jiang Q, Singh M, Qayyum S, Levrero C, Maron BA, Kaelin WG Jr. Induction of DEPP1 by HIF Mediates Multiple Hallmarks of Ischemic Cardiomyopathy. Circulation. 2024 Jun 17. doi: 10.1161/CIRCULATIONAHA.123.066628. Online ahead of print. PMID: 38881449
Lampson BL, Ramίrez AS, Baro M, He L, Hegde M, Koduri V, Pfaff JL, Hanna RE, Kowal J, Shirole NH, He Y, Doench JG, Contessa JN, Locher KP, Kaelin WG Jr. Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB. Cell. 2024 Apr 25;187(9):2209-2223.e16. doi: 10.1016/j.cell.2024.03.022. PMID: 38670073
Tamar Berger, MD, PhD was selected as a Lubin Family Foundaton Scholar.
2023
Publications:
Shi DD, Lee JH, Wang AC, Khanal J, Gao W, Kaelin WG Jr, McBrayer SK. Protocol to establish a genetically engineered mouse model of IDH1-mutant astrocytoma. STAR Protoc. 2023 May 6;4(2):102281. doi: 10.1016/j.xpro.2023.102281. Online ahead of print. PMID: 37149859 Free PMC article.
Shirole NH, Kaelin WG Jr. von-Hippel Lindau and Hypoxia-Inducible Factor at the Center of Renal Cell Carcinoma Biology. Hematol Oncol Clin North Am. 2023 Oct;37(5):809-825. doi: 10.1016/j.hoc.2023.04.011. Epub 2023 Jun 1. PMID: 37270382 Review.
Shi DD, Kaelin WG. The INDIGO trial: Precision medicine finally comes to glioma. Neuro Oncol. 2023 Nov 2;25(11):1918-1919. doi: 10.1093/neuonc/noad162. PMID: 37698505 No abstract available.
Adam Kibel, MD has been appointed the inaugural incumbent of the DiNovi Distinguished Chair in Urology at Brigham and Women's Hospital.
Nitin Shirole, PhD received a Career Enhancement Program Award- (Funded by Dana Farber/Harvard Cancer Center Kidney Cancer Spore)
2022
Diana Shi, MD was among the inaugural recipients of a Lubin Family Foundation Scholar Award.
Qinqin Jiang, PhD received a Kidney Cancer Research Program Postdoctoral Fellowship Award from DoD.
Nitin Shirole, PhD received a Hope Funds Sakonnet Fellowship- (Funded by Hope Funds for Cancer Research)
2021
Alumni News: October 2021 Javid Moslehi, MD will become Chief of Cardio-Oncology at UCSF Cardiology! Congrats Javid!!
Publication: Targeting oncoproteins with a positive selection assay for protein degraders
advances.sciencemag.org/content/advances/7/6/eabd6263.full.pdf
2020
The political battle over masks is making us lose the war on COVID-19
Opinion: Why we can’t cure cancer with a moonshot
2019
William Kaelin's 2019 Nobel Prize in Physiology or Medicine
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©2020 Kaelin Lab at Dana-Farber Cancer Institute
©2020 Kaelin Lab at Dana-Farber Cancer Institute