RECENT PAPERS
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Wyant GA, Yu W, Doulamis IP, Nomoto RS, Saeed MY, Duignan T, McCully JD, Kaelin WG Jr.  Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists.   Science. 2022 Aug 5;377(6606):621-629. doi: 10.1126/science.abm1638. Epub 2022 Aug 4. PMID: 35926043  PMCID: PMC9639781

Shi DD, Savani MR, Levitt MM, Wang AC, Endress JE, Bird CE, Buehler J, Stopka SA, Regan MS, Lin YF, Puliyappadamba VT, Gao W, Khanal J, Evans L, Lee JH, Guo L, Xiao Y, Xu M, Huang B, Jennings RB, Bonal DM, Martin-Sandoval MS, Dang T, Gattie LC, Cameron AB, Lee S, Asara JM, Kornblum HI, Mak TW, Looper RE, Nguyen QD, Signoretti S, Gradl S, Sutter A, Jeffers M, Janzer A, Lehrman MA, Zacharias LG, Mathews TP, Losman JA, Richardson TE, Cahill DP, DeBerardinis RJ, Ligon KL, Xu L, Ly P, Agar NYR, Abdullah KG, Harris IS, Kaelin WG Jr, McBrayer SK.  De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.  Cancer Cell. 2022 Aug 12:S1535-6108(22)00324-5. Doi 10.1016/j.ccell.2022.07.011. Online ahead of print.  PMID: 35985343   PMCID: PMC9515386

Stransky LA, Vigeant SM, Huang B, West D, Denize T, Walton E, Signoretti S, Kaelin WG Jr.  Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway.  Proc Natl Acad Sci U S A. 2022 Apr 5;119(14):e2120403119. doi: 10.1073/pnas.2120403119. Epub 2022 Mar 31. PMID: 35357972   PMCID: PMC9168943  

Koduri V, Duplaquet L, Lampson BL, Wang AC, Sabet AH, Ishoey M, Paulk J, Teng M, Harris IS, Endress JE, Liu X, Dasilva E, Paulo JA, Briggs KJ, Doench JG, Ott CJ, Zhang T, Donovan KA, Fischer ES, Gygi SP, Gray NS, Bradner J, Medin JA, Buhrlage SJ, Oser MG, Kaelin WG Jr. Targeting oncoproteins with a positive selection assay for protein degraders. Sci Adv. 2021 Feb 5;7(6):eabd6263. doi: 10.1126/sciadv.abd6263. PMID: 33547076; PMCID: PMC7864573

Oser MG, Sabet AH, Gao W, Chakraborty AA, Schinzel AC, Jennings RB, Fonseca R, Bonal DM, Booker MA, Flaifel A, Novak JS, Christensen CL, Zhang H, Herbert ZT, Tolstorukov MY, Buss EJ, Wong KK, Bronson RT, Nguyen QD, Signoretti S, and Kaelin WG Jr.  The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis.  Genes Dev.  2019 Dec 1;33(23-24):1718-1738.  PubMed Central PMID: 31727771.  PubMed Central PMCID: PMC6942053.

McBrayer Koduri V, McBrayer SK, Liberzon E, Wang AC, Briggs KJ, Hyejin C, Kaelin WG Jr.  Peptidic Degron for IMiD-Induced Degradation of Heterologous Proteins.  Proc Natl Acad Sci USA 2019 Feb 12;116(7):2539-2544.  PubMed Central PMID: 30683719.  PubMed Central PMCID: PMC 6377458.

Chakraborty AA, Laukka T, Myllykoski M, Ringel AE, Booker MA, Tolstorukov MY, Meng YJ, Meier SR, Jennings RB, Creech AL, Herbert ZT, McBrayer SK, Olenchock BA, Jaffe JD, Haigis MC, Beroukhim R, Signoretti S, Koivunen P, Kaelin WG Jr. Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate. Science. 2019 Mar 15;363(6432):1217-1222. doi: 10.1126/science.aaw1026.  Epub 2019 Mar 14. PMID: 30872525; PMCID: PMC7336390.

Nicholson HE, Tariq Z, Housden BE, Jennings RB, Stransky LA, Perrimon N, Signoretti S, and Kaelin WG Jr.  HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species.  Sci Signal.  2019 Oct 1;12(601). pii: eaay0482.  PubMed Central PMID: 31575731.  PubMed Central PMCID: PMC6913182SK,

Olenchock BA, DiNatale GJ, Shi DD, Khanal J, Jennings RB, Novak JS, Oser MG, Robbins AK, Modiste R, Bonal D, Moslehi J, Bronson RT, Neuberg D, Nguyen QD, Signoretti S, Losman JA, Kaelin WG Jr.  Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase.  Proc Natl Acad Sci USA. 2018 Apr 17;115(16):E3741-E3748.  PubMed PMID: 29610306.  PubMed PMID: PMC5910822.

McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr.  Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.  Cell 2018 Sept 20; 175(1):101-116.  PubMed Central PMID: 30220459.  PubMed Central PMCID: PMC6219629.

Oser MG,  Fonseca, R, Chakraborty AA, Brough R, Spektor A, Jennings RB, Flaifel A, Novak JS, Gulati A, Buss E, Younger ST, McBrayer SK, Cowley GS, Bonal DM, Nguyen QD, Brulle-Soumare L, Taylor P, Cairo S, Ryan CJ, Pease EJ, Maratea K, Root DE, Signoretti S, Pellman D, Ashton S, Lord CJ, Barry ST, and Kaelin WG Jr.  Cells Lacking the RB1 Tumor Suppressor Gene are Hyperdependent on Aurora B Kinase for Survival.  Cancer Discovery 2018 Feb;9(2):230-247.  PubMed Central PMID: 30373918.  PubMed Central PMCID: PMC6368871.